Stem cell transplantation for type 1 diabetes mellitus
نویسندگان
چکیده
BACKGROUND The use of stem cells to treat type 1 diabetes mellitus has been proposed for many years, both to downregulate the immune system and to provide beta cell regeneration. CONCLUSION High dose immunosuppression followed by autologous hematopoietic stem cell transplantation is able to induce complete remission (insulin independence) in most patients with early onset type 1 diabetes mellitus.
منابع مشابه
Fetal Pancreatic Stem-Cell Transplant in Patients With Diabetes Mellitus.
OBJECTIVES To determine the efficacy of fetal stem cell transplant for treating patients with diabetes mellitus types 1 and 2. MATERIALS AND METHODS Five patients with diabetes mellitus type 1 and 5 patients with diabetes mellitus type 2 (aged 18-56 years) received a fetal pancreatic stem-cell transplant (cells were 16-18 wk gestation) performed by intravenous infusion at 50 mL/hour. The quan...
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Background: Pancreatic islet transplantation has emerged as a promising treatment for type I diabetes. However, its efficacy is severely hampered due to poor islet engraftment and revascularization, which have been resulted to partially loss of transplanted islets. It has been shown that local delivery of vascular endothelial growth factor (VEGF) could accelerate transplanted islet revasculari...
متن کاملThe role of hematopoietic stem cell transplantation for type 1 diabetes mellitus
Júlio C. Voltarelli Carlos Eduardo B. Couri Maria Carolina Rodrigues Ana Beatriz P. L. Stracieri Daniela A. Moraes Fabiano Pieroni George Navarro Maria Isabel A. Madeira Belinda P. Simões In this review, we present 1) scientific basis for the use of high dose immunosuppression followed by autologous peripheral blood hematopoietic stem cell transplantation for newly diagnosed type 1 diabetes mel...
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The proportion of organ recipients with diabetes mellitus at the time of transplantation varies widely and depends on the primary disease necessitating transplantation (Table 1).1–5 For example, diabetes is the most common cause of renal failure requiring transplantation, whereas peripheral blood stem cell transplantation is usually performed in individuals with diseases unrelated to preexistin...
متن کاملStem cells and diabetes
Diabetes mellitus is a metabolic syndrome characterized by increased levels of blood glucose. Type 1 diabetic patients and patients with Type 2 diabetes suffering from defective insulin secretion rely on lifelong substitution with exogenous administration of insulin. Whole pancreas and purified pancreatic islet transplantation have offered the potential for independence from insulin injections....
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ورودعنوان ژورنال:
- Diabetology and Metabolic Syndrome
دوره 1 شماره
صفحات -
تاریخ انتشار 2009